Excluding stone efficiency of quercus salicina extract capsules on renal calcium oxalate mouse without renal function damage
LIANG Hui;ZHANG Jian-wen;ZHANG Sheng-ping;WANG Hong-liang;SUN Rui;ZHI Fan;MAO Deng-qi;Department of Urology,People′s Hospital of New District Longhua Shenzhen,Affiliated Hospital Southern Medical University;
Objective To explore the excluding stone efficiency of quercussalicina extract capsules on renal calcium oxalate mouse without renal function damage. Methods Glycol was used to establish the model mouse with rental calcium oxalate. 60 Wistar mice were randomly divided into four groups including control group, model group, low-quercussalicina extract capsules group and high-quercussalicina extract capsules group. The urine volume, diet volume, Ca2+, Mg2+, oxalate, citrate concentration in urine, Cr, BUN contention in serum and SOD, GSH-Px activity were detected after feeding four weeks.Results Low-quercussalicina extract capsules could discrease the volume of urine and diet, decrease the concentration of Ca2+(1.89±0.43) mmol / L and oxalate(2.02±0.02) mmol / L in urine, increase the concentration of citrate(9.03±1.02) mmol / L and Mg2+(16.3±0.23) mmol / L, decrease the Cr, BUN and oxalate concentration and increase the activity of SOD(230.19±20.69)U / mg and GSH-Px(45.53 ±5.45)U / mg. In contrast, the results of high dose group changed more significantly.Conclusion Quercussalicina extract capsules can increase the stone-preventing effect and reduce the stone formation.