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《Journal of Guangzhou University of Traditional Chinese Medicine》 2009-05
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Effect of Acupuncture on Estrogen,Estrogen Receptor and Estrogen Signal Transduction in Rat Model of Hyperplasia of Mammary Glands

GONG Dongfang1, XIE Juan2, TANG Chunzhi1 (1.School of Acupuncture,Moxibustion and Massage,Guangzhou University of TCM,Guangzhou 510405 Guangdong,China;2.Dept.of Acupuncture & Moxibustion,Loudi Central Hospital,Loudi 417000 Hunan,China)  
Objective To observe the effect of acupuncture on rat model of estrogen-mediated hyperplasia of mammary glands.Methods SD female non-pregnant rats were randomized into 4 groups: normal group,model group,acupuncture group(electro-acupuncture on acupoints of Tanzhong and Sanyinjiao),and western medicine group(gastric gavage of tribenzylamine 0.5 mg·kg-1·d-1).Except the rats in the normal group,rats in other groups received muscular injection of diethylstilbestrol(0.5 mg·kg-1·d-1) and progesterone(4 mg·kg-1·d-1) to induce hyperplasia of mammary glands.After the modeling,acupuncture group and western medicine group received the corresponding treatment for 30 days.After treatment,rats body weight and the height of the second pair of nipples were examined;serum estrogen(E2) level,and expression levels of estrogen receptor(ER),extracellular regulated kinase(ERK) and epithelial nitric oxide synthase(eNOS) were detected,and the mammary histological features were observed.Results The differences of body weight and nipple height were insignificant between the four groups before treatment(P0.05).After treatment,the nipple height was increased in the model group(P0.01 compared with the normal group),but was decreased in the two treatment groups(P0.05 compared with the model group);hyperplasia of mammary glands occurred in the model group,and acini number in lobules of the mammary gland,acinar cavity diameter and acinar ductal diameter were reduced in the two treatment groups(P0.05 or P0.01);serum E2 level and the number of mammary cells with ER,ERK and eNOS expression positive were increased in the model group(P0.01 compared with the normal group),while were decreased in the two treatment groups(P0.05 or P0.01).Conclusion The therapeutic mechanism of acupuncture for the treatment of hyperplasia of mammary glands is probably related with the regulation of estrogen signal transduction system,and with the inhibition of estrogen in promoting mammary proliferation.
【CateGory Index】: R245
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