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《Journal of Synthetic Crystals》 2006-06
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Simulation in Vitro on Inhibition of Calcium Oxalate Calculus in Lithogenic Urine by Sulfated Polysaccharide Isolated from Laminarin

WANG Qing-hao~1,ZHENG hui~2,WU Xiu-mei~2,OUYANG Jian-ming~2(1.College of Chemistry and Life Science,Gannan Normal University,Ganzhou 341000,China;2.Institute of Biomineralization and Lithiasis Research,Jinan University,Guangzhou 510632,China)  
The inhibition of calcium oxalate(CaOxa) urinary stone by sulfated polysaccharide(LSPS) isolated from marine algae Laminarin was investigated in lithogenic urine by means of scanning electron microscopy,X-ray diffraction,and Fourier transform infrared spectroscopy.LSPS can inhibit the nucleation and aggregation of calcium oxalate monohydrate(COM) crystals,and induce the formation of calcium oxalate dihydrate(COD) crystals.With the concentration of LSPS increases from 0 to 0.005,(0.02) and 0.20 mg/mL,the percentage of COD crystals increased from 0 to 22%,55% and 100%,respectively.It indicated that LSPS maybe a potential inhibitor to CaOxa urinary stones.
【Fund】: Project supported by the Key Project of Guangdong Province(2006 B 36501001)and the National Natural Science Foundation ofChina(No.20471024)
【CateGory Index】: Q811.2
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