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Cytotoxicity of Dopamine on SH-SY5Y Neurons and Related Neuroprorection

Yulin Deng, Li Tang, Lingyan Meng, Wei Yang (School of Life Science & Technology, Beijing Institute of Technology, Beijing 100081)  
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. Its pathological character is the progressive loss of dopaminergic neurons in the substantia nigra. The oxidative stress is considered the main factor leading to loss of substantia nigra. Dopamine (DA) can be auto-oxidated into 6-OHDA and neuromelanin. Our study developed the oxidative stress model induced by DA. Some drugs were employed to investigate the neuroprotection. It is not clear whether the mechanism of dopaminergic cells of PD is apoptosis or necrosis. The neurotoxicity in dopaminergic neuroblastoma SH-SY5Y cells induced by DA was examined. The results suggest that the cellular viability was significantly decreased with the higher DA concentration and in time dependent manner. The possible neuroprotection of some drugs, i.e. tBHQ, EGCG, citicoline, Nomifensine, Nitroarginine and R-2HPA was examined. The apoptosis was preliminarialy investigated and the DNA fragments were clearly displayed.
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