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An Animal Model of Caerulein-Induced Acute Edematous Pancreatitis in Rat

Yu Chonglin;Yang Pinhua;Li Ruixiang (Department of Anatomy,Luzhou Medical College,Luzhou 646000) (Department of Anatomy, West China University of Medical Sciences,Chengdu 610041)  
A model of acute cdematous pancreatitis was established in rats by subcutaneous admin- istration supramaximal doses of caerulein and the pathologic changes of the pancreatic acinar cells were observed by light and electron microscopes. The characterized changes of this model were mark edema of the pancrease,histologic changes (including interstitial edema,acinar cytoplasmic vacuoles and inflammatory cell infiltration) and rising in serum amylase. This model has many merits. As, it is simple, rapid appeared lesions,noninvasive,and it' s morphologic changes and time course closely resemble that of human pancreatitis. There-fore, it is an ideal model for study the pathogenetic mechanisms during the early phase of acute pancreatitis.
【CateGory Index】: R-332
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