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Immunohistochemical Study of Insulin Like Growth Factor Ⅰ in Some Human Fetal Organs

Wang Fan Yung Huijun Li Ruixiang Li Aidong Department of Anatomy, West China University of Medical Sciences,Chengdu 610041  
Insulin like Growth Factors (IGFs) play an important role in the cellular proliferation and differentiation of fetal organs. Using immunohistochemistry of ABC, we investigated IGF Ⅰ positive cells appearing in liver, kidney, spleen, thymus and adrenal gland of fetus from 16 to 24 weeks. The result showed that IGF Ⅰ positive cells ceuld be found in these organs during this period of fetal life, but the differences of number and reaction intensity of IGF Ⅰ positive cells appeared in different individual. The results suggest that some cells in these organs can express IGF Ⅰ during fetal development and it play paracrine and/or autocrine role in these fetal tissue cellular proliferation and differentiation.
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