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Effects of LPS on the expression of nNOS and c-Fos in the CA2-3 region of hippocampus of rats

Han xiuyin, Wang lei, Ma yuqiong, Dang jin feng, Ou kequn, Chen wenyu,zhang jian-guo (Department of histology and embryology and neurobiology , West China Center of Medical Sciences, Sichuan University, Chengdu 610041)  
Objective To investigate the role of nitric oxide (NO) and c-fos in the CA2-3 region of hippocampal neuroimmunomodulation. Method 5 rats were intraperito-neally treated LPS (600 ng/kg) to stimulate the immune system, saline substituted LPS in 5 control rats. Using immnohistochemistry and image analysis method, we observed the effects of LPS on the protein expression and optical density (OD) values of neuronal nitric oxide synthase (nNOS) and fos in CA2-3 region of hippocampus. Results nNOS and fos positive products dispersedly distributed in every region of hippocampus, The OD values of nNOS and fos positive neurons in CA2-3 region were increased with statistical significance after LPS immunization. Conclusion NO and FOS closely involved in the immunomodu-lating function in the CA2-3 region of hippocampus during LPS induced immune system activation.
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