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The Content Variation of Substance P in Hypothalamus and Spinal Cord of Pain Models of Rat

ZHANG Xiao-ying1,YANG Guo-dong2,SHE Yong-hua1,CAI Chang-ping1(1.Department of Anatomy,North-Sichuan Medical College,Nanchong Sichuan 637400;2.Department of Gastroenterology,Affiliated Hospital of North-Sichuan Medical College,Nanchong Sichuan 637400)  
Objective To investigate the content variation of Substance P(SP) in hypothalamus and spinal cord of pain models of rat with radioimmunoassay(RIA).Methods Rats were divided randomly into blank control group,saline group(injected subcutaneously 0.9 % NaCl into left voix pedis) and pain model group(injected subcutaneously 5%formaldehyde into left voix pedis).The immunoractive SP in femoral artery,hypothalamus and spinal cord was detected by RIA.Results The content of SP in femoral artery,hypothalamus and spinal cord was different significantly in pain group than that in other control groups(P0.05),but no difference between two control groups(P0.05).Conclusion The up-regulation of SP in femoral artery,hypothalamus and spinal cord implied that the subcutaneous injection of formaldehyde may induce the sterile inflammatory response and result in the symptom of pain.
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