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The Impaired Effects of Cadmium and the Protective Effects of Testosterone on Mitochondria of GCT Cells In Submandibular Gland of Male Rats

LI Xin-zhi1,LIAO Xiao-gang2(1.Department of Anatomy and Histology & Embryology,Chengdu Medical College,Chengdu 610083,China; 2.Laboratory of Electron microscopy,Chongqing University of Medical Sciences,Chongqing 400016,China)  
Objective To Investigate the impaired effects of low-dose cadmium chloride and the protective effects of testosterone propionate on mitochondria of GCT cells in submandibular gland of male rats.Methods Thirty-five male adult Wistar rats were randomly divided into three groups: control group,Cd injecting group and Cd + T injecting group.The morphologic changes of GCT cells were observeded by transmission electron microscopy,and the quantitative analysis were performed on mitochondria with image-plus-pro analysis system.Results The mainly ultrastructural changes after injecting Cd in 24 hours included swelling and/or vacuolation of mitochondria,increasing of myelin figures in cytoplasm and mitochondria of GCT cells,which were most prominent in 7-15d,moreover,the changed morphology of GCT cells didn′ t recover in 30d.On the other hand,the ultrastructural lesions of GCT cells in Cd+T group were gentler compared with Cd group.In image analysis,there was significant difference between Cd group and control group in 3-15d(P0.05),and between Cd+T group and control group in 7d and 15d(P0.05).Conclusions The present study indicate that the ultrastructure of mitochondria will be injured by cadmium.Furthermore,supplying testosterone can prevent the mitochondria in GCT cells from toxicity of cadmium.
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