Expressions of PEA3 in Cerebral Cortex of Mice
Jing Yuping1 Shen Wenying1 Zheng Jianguo1 Song Bencai2 Dong Dacui21 (Medical College of Hubei Vocational-Technical College,Xiaogan 432000,China)2 (Department of Anatomy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)
Objective To investigate the expression and change of PEA3 and GDNF in cerebral cortex of mice and to explore the relationship between PEA3 expression and neural development via histomorphological charateristics. Methods About 5μm tissue sections were obtained respectively from frontal lobe,emporal lobe and parietal lobe of Kunming mice born on 1st、5th、10th、20th、30th and 40th day. The experssion of PEA3 were determined by immunohistochemistry using SABC method. Results In this experiment,the average optical density of the PEA3 positive expression was found not significant differences among 1st-day,5th-day,10th-day and 20th-day groups(P0.05),then was droping in 30th-day group,finnaly increasing in 40th-day group in spite that was lower than that of 1st-day,5th-day,10th-day and 20th-day groups. Conclusion PEA3 plays a role during the development of the cerebral cortex after birth,which may be more important before 20 postnatal days; PEA3 expression in different parts of the cerebral cortex changes was not uniform.