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Meta-analysis on Olanzapine in the Treatment Negative Symptoms of Schizophrenia

Tian Yun1 Zhong Zhanqiong2 1 (School Hospital of Chengdu Medical College,Chengdu 610083,China) 2 (Grade 2007 of Pharmacy Faculty of Chengdu Medical College,Chengdu 610083,China)  
Objective To study efficacy and side effects of olanzapine in the treatment of schizophrenia with negative symptloms using Meta-analysis. Methods Case-control studies involved in the relationship to olanzapine on treatment negative symptoms of schizophrenia were retrieved from CNKI,VIP and EMCC databases. All statistical analyses were performed with RevMan4.2 software.Results 18 eligible articles were selected in this study,including a total of 696 cases in the treatment group and controls group. The meta analysis of combined data statistics revealed that olanzapine on treatment negative symptoms of schizophrenia systematic data was z=10.97(P0.00001). Furthermore,the results of sensitivity analysisis were shown to be the same to results of this study.Conclusion The treatment of olanzapine on negative symptoms of schizophrenia is effective.
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