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Effect of Exercise Training on MuRF1 Expression in Disused Skeletal Muscle

Lv Kunru Yang Yueqin Wang Song Chen Guoqing1(Department of Health Science,Wuhan Institute of Physical Education,Wuhan 430079,China)2(Central Laboratory,Wuhan Institute of Physical Education,Wuhan 430079,China)  
Objective The aim of this study was to investigate the impact of exercise training on atrophied muscle expression of MuRF1.Methods We established the disuse skeletal muscle atrophy model by tail suspension for 4 weeks.The muscle fiber size and level of oxidative stress of gastroenemius was detected,and the MuRF1 gene and protein expression were examined by immunohistochemistry and RT-PCR,respectively.Results The fiber size of gastroenemius was significantly decreased after 4 weeks' tail suspension,while the MuRF1 gene and protein expression were increased significantly.And regular exercise training could restore the atrophied muscle and down-regulate the expression of MuRF1 significantly.Conclusion Our results indicate that MuRF1 gene may play an important role on disuse skeletal muscle atrophy and regular exercise training exhibits great potential to restore the muscle atrophy by reducing the expression of MuRF1.
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