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Experience of Prepation for TypeⅠ Diabetic Rat Model

Li Nana1 Ma Shujun2 Zhou Li11(Department of Human Anatomy,Xinxiang Medical College,Xinxiang 4530032,China)2(Department of Inspection,Xinxiang Medical College,Xinxiang 4530032,China)  
Objective To explore the method of establishing typeⅠ diabetic rat model.Methods SD rats were injected intraperitoneally with 55 mg/ kg streptozotocin(STZ) once to induce the typeⅠ diabetes models.Results The rats in experimental groups had typical typeⅠ diabetic symptoms,such as the increase of diet,drinking,urine and the decrease of body weight.Compared with normal groups,the weight of rats was decreased significantly in experimental groups(P0.05).Compared with normal groups,the blood suger of rats in experimental groups was increased significantly(P0.05).There were significant differences between each experimental group(P0.05).Conclusion Rat model with typeⅠ diabetes mellitus could be induced by injecting intraperitoneally high dose STZ into rats.
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