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Glutamine Synthetase in the Role of Epileptogenesis

Liu Baojun Kan Zhisheng Liu Feng(The neurosurgery department,Hospital of Kailuan Co.,Ltd,Tangshan 063000,China)  
As a common chronical clinical syndrome,many factors and moleculars are involved in the process of epileptogenesis and the mechanism of it is very complex.Glutamine synthetase is a capital enzyme involved in glutamate metabolism,its change can result in the disorder of epilepsy,but the research results are not complete in the same,the most result leading to the result that the decreased expression and activity of GS might play a role in repeated kindling of seizure,but the most of researching was done in vitro or section of animal brain,it has the different result in vivo,so there was more researching to reveal the relations of the GS and the epilepsy.
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