Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Sichuan Journal of Anatomy》 2012-01
Add to Favorite Get Latest Update

Comparison on the Clinical Effect of Lusartan and Amlodipine in Patients with Hypertension

Gu Qing Hao Yinglu(Department of Cardiac Medicine of Yuxi People's Hosipital,Yuxi 653100,China)  
Objective To compare the effect of losartan and amlodipine in primary hypertension patients on blood pressure,uric acid and left ventricular hypertrophy.Methods The 128 patients with hypertension combining left ventricular hypertrophy were randomly divided into group L(losartan 50mg qd,n=65) and group A(amlodipine 5mg qd,n=63).Changes of blood pressure and serum uric acid was observed after 12 weeks treatment.Left ventricle diastolic dimension(LVDd),interventricular spetum thickness(LVST),left ventricle mass index(LVMI),left ventricle posterior wall thickness(LWPVT) were measured by ultrasound cardiography before and after 12 week's treatment respectively.Results The blood pressure significantly decreased on week 12 in group L and group A(P0.01),and there was no significantly difference between group L and group A(P0.05).While hyperuricemia significantly decreased in losartan group(P0.05);Serum uricacid scarcely changed in amlodipine group(P0.05).The LVDd,LVSd,LVPWd and LVMI of group L decreased significantly(P0.01) but rarely changed in group A(P0.05).Conclusion Losartan has the same effect on blood pressure with amlodipine,besides,losartan has the clinical effect on decreasing serum uric acid and left ventricular hypertrophy.
【CateGory Index】: R544.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved