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Observation of the Endogenous Neural Stem Cells After Fimbria Fornix Transection

Zou Linqing Jin Guohua Zhang Xinhua Qin Jianbing Tian Meiling(Dept.of Human Anatomy,Medical School,Nantong University,Nantong 226001,China)  
Objective To investigate the proliferation of the endogenous neural 1stem cells(NSCs) in the bilateral fimbria fornix of adult rat after unilateral fimbria fornix transection.Methods The right fimbria fornix of SD rats were transected,then on postprocedural day 2 performed 5-bromodeoxyuridine(BrdU) injection intraperitoneally once a day for 5 days.On postprocedural day 7,the brains were fixed for frozen section,and the proliferation of NSCs was detected by BrdU/Nestin double-label immunofluorescence assay.Results The number of BrdU positive cells and Nestin positive cells in the transected side's fimbria fornix were more than those in the normal side.Many BrdU/Nestin double labeled cells were observed in the transected side's fimbria fornix,but absent in the normal side's fimbria fornix.Conclusion Fimbria fornix transection could cause endogenous NSCs in brain to proliferate rapidly and migrate into fimbria fornix.
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