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The Signal Pathway of Cell Apoptosis

Li Xiaoting1,2 1(College of Basic and Forensic Medicine,Sichuan University,Chengdu 610041,China) 2(Leshan vocational and technical college,Leshan 614000,China)  
The present study of apoptotic signaling pathway most focus on wnt and JNK two pathways.The wnt pathway contain three branches,i.e.,classic wnt pathway,wnt/PCP pathway and wnt calcium channel,.The main mechanisms of cell apoptosis are through β-Catenin/ tcf transcription regulatory pathways and APC activation pathway.The JNK signal pathway is transducted through MKKKs-MKKs-MAPK.The activation of JNK signaling pathway perform through phosphorylation of transcription factors,cytoskeletal associated proteins,enzymes and other substrates so as to regulate cellular physiological processes,ultimately lead to cell apoptosis.
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