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《Sichuan Journal of Anatomy》 2013-01
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Research Progress on HBV PreS1 Protein

Yi Tao(Gynecological Tumor Biotherapy Laboratory,West China Second Hospital,Sichuan University,Chengdu 610041,China)  
Hepatitis B virus(HBV),one of the leading causes of hepatocellular carcinoma and liver diseases,is a DNA virus of the hepadnaviridae family.Hepatitis B virus(HBV) infections constitute a major global health problem.Hepatocellular carcinoma is one of the most serious malignant tumor in the world which are considered as the third cancer-associated cause of deaths worldwide.Although our knowledge about the molecular biology of this highly liver-specific virus has increased,the mechanism of attachment and entry into its host cell is still unknown.The HBV PreS1 protein is located on the HBV surface and plays an important role in viral infectivity and assembly.To block HBV entry and against viral infection,a couple of approaches based on PreS1 peptides are currently under investigations,which have the potential to become novel antiviral therapeutics.
【CateGory Index】: R373
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 Li Xiuhui; Luo Kangxian; Tian Qiqi et al(Beijing Youan Hospital, Beijing 100054);Anti-PreS1 Reflects both the Hepatocellular injury and virus Clearance[J];CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY;1994-02
2 Wei-Guo Hu, Jun Wei, Heng-Chuan Xia, Xin-Xiu Yang, Feng Li, Guang-Di Li, Yuan Wang, Zu-Chuan Zhang, Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, PR China Jun Wei, Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA;Identification of the immunogenic domains in HBsAg preS1 region using overlapping preS1 fragment fusion proteins[J];世界胃肠病学杂志(英文版);2005-14
【Co-citations】
Chinese Journal Full-text Database 8 Hits
1 LIN Chao-shuang1,WANG Xiang-yang2,GAO Zhi-liang1.1 Department of Infection Diseases,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,China;2 Guangdong International Travel Health Care Center,Guangzhou 510635,China;Current situation of inoculation and search on the non-responsiveness to hepatitis B vaccine[J];International Journal of Internal Medicine;2008-01
2 Liang Xinmei from Inspection Section of Tianjin TCM Hospital(Tianjin,300451);Clinic significance of Pre-S1 protein in detection of Hepatitis B[J];Port Health Control;2009-03
3 ZHU Zuo min,GAO Zhi rong,ZHANG Peng,YANG Zhong hua(Department of Clinical Laboratery,Beijing Chaoyang Hospital, Affilited Capital University of Medical Sciences,Beijing 100020,China);Clinical Significance and Determinations of PreS1 Antigen in Patients with Hepatitis B[J];Shaaxi Journal of Medical Laboratory Sciences;2002-03
4 XU Wan-ju, ZHAO Li, TIAN Xiu-qing (Shandong Provincial Qianfoshan Hospital, Ji'nan, Shandong 250014, China);Pre-S_1 Ag of Hepatitis B Virus:Its Determination and Clinical Significance[J];Journal of Practical Medical Techniques;2006-03
5 CHEN Hai-wei,WU Yong,CHEN Dao-jin(Department of Clinical Laboratary,The Third Xiangya Hospital of Central South University,Changsha,410003,China);Determinations of PreS1 antigen in patients with hepatitis B and its clinical significance in tumorigenesis in primary hepatic cancer[J];Journal of Practical Oncology;2006-06
6 DING Guo-xiang,WANG Zhi,WANG Li,et al.(The Fourth Hospital of Qinghai Province,Xining 810000,China);COMPARATIVE ANALYSIS OF THE RESULT OF HEPATITIS B VIRUS DETECTED BY MEIA WITH PRES1AG AND DNA[J];Modern Preventive Medicine;2007-24
7 Ying Sun, Postgraduate Medical School of Chinese PLA, Beijing 100853, China Shao-Jie Xin, Li Lei, Jun Hou, Pan-Yong Mao, Department of Virology, Institute of Infectious Disease, 302 Hospital of Chinese PLA, Beijing 100039, China;Significance of hepatitis B virus large protein detection in prediction of HBV DNA replication[J];World Chinese Journal of Digestology;2006-03
8 Feng Fumin; Mi Zhibao; Zhang Xitan; et al.(Institute of Microbiology and Epidemiology,AMMS,Beijing 100071);Detection of anti-PreS_1 antibody in serum using PreS_1 synthetic peptide[J];CHINESE JOURNAL OF MEDICAL LABORATORY SCIENCES;1995-03
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