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Serum MMP-9,TIMP-1and Hs-CRP in Expression in Gerontal Patients with Aortic Sclerosis Plaque

Yang Hua;Wang Quandong;Department of geraeology,The First People's Hospital of LianYunGang;  
Objective The aim of the study was to evaluate serum matrix metalloproteinase(MMP9),tissue inhibitors of metalloproteinase 1(TIMP-1)and High-sensitivity C-reactive protein(Hs-CRP)expression in gerontal patients with aortic sclerosis plaque.Methods 90patients were recruited.The intima-media-thickness(IMT)and plaques of carotid artery were measured.The serum MMP9,TIMP-1and Hs-CRP were measured by ELISA.Results According to ultrasonic diagnosis the patients were divided into endometrial coarse group(28patients),stable plaque group(32patients)and unstable plaque group(30patients).The statistically significant higher levels of MMP9and Hs-CRP were noticed in the patients with unstable plaque(P0.05).there were no significant difference of MMP9and Hs-CRP between the endometrial coarse group and stable plaque group(P0.05)Serum TIMP-1levels significant lowerr in unstable plaque group than the endometrial coarse group and stable plaque group(P0.05). there were no significant deviation of TIMP-1between the endometrial coarse group and the stable plaque group(P 0.05).Conclusion The serum MMP-9,TIMP-1and Hs-CRP expression were association with carotid atherosclerotic plaques and may be used to identify vulnerable plaques.
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