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The Research Progress of Endothelial Glycocalyx

Yao Xinghong;Zeng Ye;State Key Laboratory of Oncology in South China,Department of Radiation Oncology,Sun Yat-Sen University Cancer Center;Institute of Biomedical Engineering,School of Preclinical and Forensic Medicine,Sichuan University;  
Endothelial glycocalyx covered the vascular endothelial cell surface,which played important roles in vascular physiology and pathology.It has been demonstrated that the endothelial glycocalyx can impact on the endothelial cell functions,regulate the blood cell-endothelial cell interactions,and prevent the leucocyte adhesion.It has been shown that the endothelial glycocalyx is also a barrier with selective permeability for the vascular wall and a mechanosensor of hydrodynamic shear stress.An overview is given of the structure and function of glycocalyx,the commonly used research techniques,and our observation of shear stress-induced remodeling of glycocalyx.
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