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《Sichuan Journal of Anatomy》 2014-01
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The Gene Expression of Vimentin In Spinal Cord Contusion Rat Detected by Real-Time PCR

Qian Baojiang;Xia Qingjie;Wang Tinghua;Institute of Neuroscience,Kunming medical University;Institute of Neurological Disease and Translation Neuroscience Center,West China Hospital,Sichuan University;  
Objective This study aimed to investigate Vimentin gene expression change at different time following spinal cord contusion.Methods Adult female SD rats were randomly divided into four groups:Sham group;spinal cord contusion 6h group;spinal cord contusion 5d group;spinal cord contusion 14d group.Real-Time PCR was used to investigate the Vimentin gene expression at 6h,5d,14d following spinal cord contusion.Results Real-Time PCR found that fewer Vimentin expression in sham group.An significant increasing expression of Vimentin was discovered in contusion 6h group compared with sham group(P0.01),which reached peak.Moreover,Vimentin expression gradually decreased in contusion 5d and 14d group,which Vimentin expression was significantly lower than 6h group(P0.01),and the expression of Vimentin closed normal level in contusion 14d.Conclusion The gene expression of Vimentin increased rapidly in the early stage of spinal cord contusion rats,and gradually returned to normal levels in 14d contusion rats.Those suggested that vimentin gene expression change involved in the mechanism of spinal cord contusion.
【CateGory Index】: R651.2
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