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Research on Factors and Drug Resistance of Intracranial Infection after Craniotomy in Patients with Severe Craniocerebral Trauma

Yuan Gaoming;Meng Xiaofeng;Wang Lulu;Guo Xiaolong;Cui Tao;Cheng Xiaobing;Hao Xiaowei;Shi Baozhong;Department of Neurosurgery,First Affiliated Hospital of Henan University of Science and Technology;School of clinical medicine of Henan University of Science and Technology;  
Objective This study aimed to study the factors affecting intracranial infection after craniotomy in patients with severe craniocerebral trauma and the drug resistance. Methods A total of 150 patients who underwent craniotomy for severe craniocerebral trauma in our hospital from January 2013 to March 2016, were reviewed to explore the influencing factors of intracranial infection after craniotomy in patients with severe craniocerebral trauma, and to cultivate pathogenic bacteria in patients with craniotomy and analyze their drug resistance. Results There were 16 cases of intracranial infection in 150 patients with severe craniocerebral trauma, and the infection rate was 10.67%. Sixteen strains of pathogenic bacteria were cultured in cerebrospinal fluid of patients with intracranial infection, including 10 strains of gram-positive bacteria and 6 strains of gram-negative bacteria. The results of Logistic regression analysis showed that operation time(≥4 h), operation times(≥2), incisional cerebrospinal fluid leakage and ventricular external drainage were independent risk factors for intracranial infection after craniotomy, and the difference had statistical significance(P0.05). Conclusion Patients with intracranial infection after craniotomy are more likely to have intracranial infection with gram-positive bacteria and gram-negative bacteria, with longer operation time, more operation times, and the presence of incision cerebrospinal fluid leakage or external ventricular drainage.
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