Effect of Kappa-Selenocarrageenan on the levels of lipid peroxidation of heart, liver, kindney and serum in aged rats
Zhou Chunyang, et al (Department of Pharmacology, North Sichuan Medical College Nanchong 637007)
In the prcnscnt study, we use two different dosage (72mg/kg and 12mg/kg) of Kappa-seleno-carrageenan(k-SeC) ig aged SD rats for 4 months, then measured the malondialdehyde (MDA) con- centrations of the heart, liver, kidney and serum and detected the pathological changes of heart, liver and kindey. In the 72mg/kg K-SeC groups rats, except the male liver and the female kidney, MDA concentrations of hearts, liver, kidney and serum increased slightly but insignificantly. In the 12mg/ kg K-SeC groups, MDA concentrations of hearts elevated significantly while other experimental organs and serum decreased significantly excluding the female livers. The pathological changes of all groups had more or less congestion, cloudy swelling, vacuolar degeneration. Sudan black staining found more granules in the 72mg/kg K-SeC groups. Our results indicated that large dosages of K-SeC may cause toxic effect while the small dosages of K-SeC can decrease the lipid peroxidation of some organs but increase the hearts MDA concentration.