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《Sichuan Journal of Physiological Sciences》 2007-01
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Construction of the animal model with colpitis and cervicitis

Zhao Yuan,Zhou Xin-e,Shi Yuan-e,Wang Bo-yao,Huang Ning(Research Unit of Infection and Immunity,West China Medical Center,University,Chengdu,Sichuan 610041,China)  
Objective:To research the rat model with colpitis and cervicitis by phenol slurry.Methods:Removal the rat's ovary,inject estradiol benzoate and hydrocortisone,to result in fake estrum and general immunity hypofunction,then phenol slurry with 1 ml/kg were injected into rat endovaginal,on altermate days once,together three times,the changes of the pudendum observed for every days.On the fifteenth day,to take eyeball blood and determine total white blood cells by microscopic after weighing,the model rats were killed by decolation,the weight of the vagina and cervices were taken and quantified,then its index examined and calculated by pathology.Results:Swell and excreted pus appeared in the vagina orifices;cervical hypertrophy,degeneration necrosis or desquamation appeared in the vagina and cervices mucous cellula epithelialis.Under the vagina and and cervices mucous membrane,inflammation cells soakage and acestoma hyerpdlasia were discovered.Glandular organ have different degree hyperplasia and squamous metaplasia;total white blood cells obviously raised up,loss of weight.Conclusion:The colpitis and cervicitis model were constructed succesful,in order to research HMGN2 in the model with colpitis and cervicitis.
【Fund】: CMB基金98-681;; 国家自然科学基金3047076330671963资助
【CateGory Index】: R-332
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