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《Sichuan Journal of Physiological Sciences》 2007-01
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Anti-hypoxia effect of comound glycyrrhiza oral solution

Lu Li2,Liang Lang1,Zhang Xiao1(1.Department of Experimental Technology,Chengdu Meidical College;2.Clinical Class of 2004,Chengdu,610083,China)  
OBJECTIVE:To study the anti-hypoxia effect of Compound Glycyrrhiza Oral Solution in mice.Methods: ①Anti-hypoxia experiment under normal pressure : put the control group and experimental group mice into 350ml ground wide-mouth bottles respectively and observe their survival time with the last time breath as index.②Bearing swimming test: put the mice into a pool with water of 20.0±0.5 temprature,20cm deep,then observe their survival time untill their head in the water last for 10 seconds.③Experiment of protecting myocardial from anti-gypoxia:anesthesia each mice with 20% urethane(2 g/kg),then fix the back,separate the windpipe,observe the electrocardiogram,close the windpipes by thread,write down the time the electrocardiogram lasting for.Results: ①:Anti-hypoxia experiment under normal pressure:the living time of the oral solution group was obviously longer than the control group [(61.54±5.93);(52.05±20.21)min;t=5.483;p0.01];②Bearing swimming experiment:Oral Solution group surviving time was markedly longer than the control group [(28.64±2.78);(19.34±5.14)min;t=4.429;p0.01]③Experiment of protecting myocardial from anti-hypoxia:the electrocardogram lasting for of the Oral Solution group was longer than the control group[(7.76±2.23);(5.94±2.30)min;t=2.555;p0.01].Conclution:Compound Glycyrrhiza Oral Solution has obvious anti-hypoxia effect.
【Fund】: 成都医学院院长基金资助(05Z2005-009)
【CateGory Index】: R285.5
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