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《Sichuan Journal of Physiological Sciences》 2007-01
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The protective effect of total Ginsenosides of stem and leaf on elastic and collagenous fiber on skin of aging mice

Li Lian-kun1,Cheng Jun-lin2,Zhao Yan-yan2,Fan Ai-lan2(1.Chengdu Hospital of sichuan Armed Police Forcess;2.Department of Pharmacology,school of Preclinical and Forensic Medicine Sichuan University,Chengdu 610041)  
Objective:To investigate the protective effect of Ginsenosides on elastic fiber and collagenous fiber in skin of the aging mice.Methods: The aging mice model was made by subcutaneous administration in cervix with a dose of D-galactose(1000 mg·kg-1)daily for 42 days.At the same time,the aging mice took Ginsenosides(50 mg·kg-1or 100 mg·kg-1) orally.After 42 days the skin tissue was fixed in 10% formaldehyde and the elastic fiber and collagenous fiber were checked.Results: Ginsenosides of 50 mg·kg-1 and 100 mg·kg-1 once daily for 42 d could significently increase the amount of elastic fiber and collagenous fiber in skin of the aging mice.And the effect of Ginsenosides of 100 mg/kg·d-1 is more remarkable.Conclusion:Ginsenoside has remarkable protective effect on elastic fiber and collagenous fiber in skin of the aging mice.
【CateGory Index】: R285.5
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