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《Sichuan Journal of Physiological Sciences》 2008-02
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Expression of cIAP1,cIAP2 and XIAP in clear cell renal cell carcinoma and its correlation with clinicopatholgic features

Chen Shu-ni,Chen Ni,Yang Bin,Zhang Yu-tao,Zhou Qiao(Department of Pathology,West China Hospital,West China Medical School,Sichuan University,Chengdu 610041,China)  
Objective:The investigation aims to evaluate the expression status of cIAP1,cIAP2 and XIAP in CCRCC and normal kidney,and to analyze its correlation with clinicopatholgical features.Methods:The expression status of cIAP1,cIAP2 and XIAP mRNA in 20 CCRCC and paired tumor-free adjacent normal kidney was assessed by RT-PCR,its correlation with clinicopathological features analyzed.Results:RT-PCR analysis showed that expression rates of cIAP1 and cIAP2 mRNA in CCRCC were 85%(17/20)and 60%(12/20),much higher in CCRCC than in normal kidney.Semiquantitatively the level of cIAP1 mRNA was higher in grade1+2 than in grade3+4.The expression of XIAP was not different between CCRCC and normal kidney,nor correlated with Fuhrman nuclear grade or tumor stage.Conclusions:The expression of cIAP1 is negatively correlated with Fuhrman nuclear grade in CCRCC.
【Fund】: 国家自然科学基金(No.30125023 No.30570692 No.30021001);; 科技部基础研究前期专项基金(No.2002CCA01400)资助
【CateGory Index】: R737.11
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Chinese Journal Full-text Database 7 Hits
1 CHEN Fuhui, QU Hongyan, SUI Guangjie Department of Respiratory Medicine, The Second Clinical College of Harbin Medical University, Harbin 150086, China; Department of General Surgery, The Third Clinical College of Harbin Medical University, Harbin 150040, China; Department of Medical Oncology, The Third Clinical College of Harbin Medical University, Harbin 150040, China;Effects of apoptosis protein XIAP inhibitor on the apoptosis and sensitivity of chemotherapy in A549 cell[J];Chinese Journal of Lung Cancer;2008-03
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3 ZENG Liang1,WU Sheng-qi2,WANG Hui3,CHEN Sen-lin1,CHEN Yan-ping3(1 Department of pathology,Hunan Tumor Hospital;2 Medical Research Center;3 Department of Radiotherapy,Hunan Tumor Hospital,Changsha 410013 China);Research on the Effect of Survivin on Apoptosis and Proliferation of Lung Cancer Cell by RNAi[J];Progress in Modern Biomedicine;2009-02
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5 CHEN Wei, HE Xin-ping, YANG Fei-ke(Department of Gastroenterology, Central Hospital of Changsha City, Changsha, Hunan 410004, P.R.China);Implication and expression of XIAP in pancreatic carcinoma tissues[J];China Medical Engineering;2008-02
6 ZHAO Wen-jiang1,AN Ya-wei1,QIN Hong1,ZHANG Rui-feng1,LI Jian-ying1,HAO Jian-jun1,BIAN Yong-sheng1,LI Yong2.(1.Department of Surgery,Baoding First Hospital,Baoding 071000,China; 2.Department of Surgery,the Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China);Progress in Studies of Relationship of Livin and caspase-9,p53 in Gastric Carcinoma Tissues[J];Medical Recapitulate;2008-20
7 GE Li-ping,LI Jian,CHEN Ping;Expressions of Survivin and XIAP mRNA in Non-small Cell Lung Cancer[J];China Cancer;2009-01
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