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《Sichuan Journal of Physiological Sciences》 2013-01
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Protective effects of resveratrol on LPS induced HUVEC cells by regulating cytokines

Sun Yu-hong,Zhang Zhuo,Li Xiao-bing,Wang Lu-lu,Xiao Shun-han(Department of Pharmacology,Luzhou Medical College,Sichuan Luzhou 646000)  
Objective: To observe the protective effects of resveratrol on protecting LPS induced HUVEC cells by regulating cytokines.Methods: HUVEC cell lines were cultivated and induced by 0.1 μg·ml-1 LPS,different concentrations of resveratrol were administrated,cell viability was measured by cell counting kit-8;IL-6 and PGE2 were detected by enzyme linked immunosolbent assay(ELISA).Results: Compared with the model group,5μmol·L-1 resveratrol could improve the cell viability,inhibit the content of IL-6 and PGE2 in a dose-dependent manner markedly(P0.05).Conclusion: Resveratrol have protective effects on HUVEC cells induced by LPS,and it may be related with inhibiting cytokines release.
【Fund】: 四川省教育厅课题(编号:102c099);; 泸州市科技局课题(编号:2012s36)
【CateGory Index】: R285.5
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