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《Sichuan Journal of Physiological Sciences》 2016-01
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Effects of berberine on ovalbumin sensitized ileum smooth muscle strips of guinea pig

Qiu Yi;LuZhou TCM Hospital of Sichuan Province;  
Objective:To study the effects of berberine on ovalbumin sensitized ileum smooth muscle strips of guinea pig.Methods:The effects of berberine(20~100μg·ml-1)on the contraction of ovalabumin sensitized ileum smooth muscle strips were observed by ex vivo evaluation methods,and the effects of berberine(20~320μg·ml-1)on the contraction of ileum smooth muscle strips induced by His/Ach were also observed.Results:Berberine(20~100μg·ml-1)could significantly inhibited the contractility of sensitized ileum smooth muscle,and partly inhibited the contraction induced by His/Ach.Conclusion:Berberine has significant antispasmodic activity on ovalbumin sensitized ileum smooth muscle strips of guinea pig.
【Fund】: 泸州市卫生科技项目(编号:2005-05)
【CateGory Index】: R285.5
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