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Prevention and treatment effects of puerariae anti-inebriation capsule on acute alcohol intoxication mice

Yan Qiao-lu;Yin Xue-yan;Xu Li;Clinical College,Dali University;Pre-Clinical College,Dali University;  
Objective:To study the prevention and treatment effects of puerariae anti-inebriation capsule on mice with acute alcohol intoxication.Methods:Jump experiment:Thirty Kunming mice were randomly divided into three groups(n=10).Control group:each mouse was given 50% alcohol by intragastric administration(dosage,0.2 ml·10g-1).Drug-treatment group:each mouse was fed with the solution of puerariae anti-inebriation capsule(concentration,12mg·ml-1,dosage,0.2ml·10g-1),then with 50% alcohol(dosage,0.2ml·10g-1)after one hour by the way of intragastric administration.Non-drug treatment group:all mice were given normal saline(dosage,0.2ml·10g-1),one hour later,fed with 50%alcohol(dosage,0.2ml·10g-1)through the way as before.When finishing conductions of each group respectively,mice were put on a single pole after ten minutes,to observe the length of time the mice stay on the pole.Morris water maze experiment:Another thirty Kunming mice which have been trained with Morris water maze experiment were randomly divided into three groups(n=10).Control group:50% alcohol(dosage,0.2ml·10g-1)was given to each mouse in this group by intragastric administration.Then the mice were launched to Morris water maze after twenty minutes.Drug-treatment group:first,all mice which were divided into this group were received 50% alcohol(dosage,0.2ml·10g-1)by intragastric administration.Second,they were treated with the solution of puerariae anti-inebriation capsule(concentration,12mg·ml-1,dosage,0.2ml·10g-1)by intraperitoneal injection ten minutes later.Third,they were launched to Morris water maze after another ten minutes.Non-drug treatment group:In this group,the mice were treated as the same way as drug-treatment group excepting the second step.At the second step,the mice of non-drug treatment group were only given normal saline(dosage,0.2ml·10g-1)by intraperitoneal injection ten minutes after the first step.In this experiment,we need to observe whether the mice could find and climb the platform or not,and the number of mice which successfully climb the platform,as well as the average speed of swimming.Results:In jump experiment,the time of staying balance of drug-treatment group(average time,266.9±52.4s)was obviously longer than non-drug treatment group(average time,173.5±74.1s)and control group(average time,155.8±54.8s)(P0.01).In Morris water maze experiment,the number of mice which could find and climb the platform were significantly increased in drug-treatment group,as compared to control group.The average speed of swimming of drug-treatment(average speed,17.2±9.4cm·s-1)was faster than non-drug treatment group(average speed,8.02±4.8cm·s-1)and control group(average speed,7.01±4.8cm·s-1)(P0.05).Conclusion:Puerariae anti-inebriation capsule has the prevention and treatment effect on acute alcohol intoxication to a certain degree.
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