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Effect of blood samples collected from heart and common carotid artery on the half-life of plasma sodium salicylic in rabbits by HPLC

Wei Ying;Chen Zhen;Ma Xue;Yang Mei;Liu Dan;Liao Rong-qiong;Chen Xiao-yun;Zhang Yu;Wang Ling-ling;Tian Rui-min;School of Pharmacy,North Sichuan Medical College;North Sichuan Medical College;  
Objective:To observe the effects of blood samples were collected from heart and common carotid artery on the half-life of plasma sodium salicylic in rabbits.Methods:Twelve rabbits were divided into two groups(n=6)according to the random number and single blind method.Blood samples collected from one group were from heart and another from the common carotid artery.Rabbits were injected 10% sodium salicylic solution 2ml kg-1 through ear vein.Blood samples were collected at 0,10 and 40min respectively from heart and common carotid artery to measure the half-life of plasma salicylic sodium by high performance liquid chromatograph(HPLC).Results:The half-life in the groups whose blood samples were collected from heart were significantly longer than those in another groups(P0.05).The experimental data in the groups whose blood samples were collected from common carotid artery were more stable.Conclusions:The blood samples from common carotid artery are more stable than those from heart on the half-life of plasma sodium salicylic.
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