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《Sichuan Journal of Physiological Sciences》 2017-01
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Effect of edaravone on viral encephalitis patients in serum protein metabolism

Liu Chao-feng;Department ofNeurology,Nanshi Hospital;  
Objective:To investigate the effect of edaravone on viral encephalitis patients in serum protein metabolism.Methods:From February 2015 to June 2016,120 adult patients with viral encephalitis were selected in our hospital.According to the principle of random envelope,patients were divided into observation group and control group,60 cases in each group.The patients in control group were given intravenous acyclovir therapy,and the patients in observation group were given intravenous infusion of edaravone therapy based on the control group.The two groups were all treated with 21 d.The changes of C reactive protein in two groups before and after treatment and complications during treatment,including epilepsy,incontinence,behavioral change were observed.Results:After treatment,the serum CRP of the observation group and the control group were 11.18 ± 4.19 mg · L~(-1) and16.22±3.82mg·L~(-1), which were significantly lower than that of before treatment, 22.13 ± 3.19 mg · L~(-1) and22.99±2.81mg·L~(-1)(P0.05),and the serum CRP of the observation group was significantly lower than that of the control group(P0.05).The incidence of epilepsy,incontinence,behavior change in the observation group during treatment were 8.3%,which was significantly lower than that in the control group(25.0%)(P0.05).Conclusion:Edaravone can inhibit the release of serum C-reactive protein,reduce the incidence of complications,with the role of adjuvant therapy of viral encephalitis,which can significantly improve the prognosis.
【CateGory Index】: R512.3
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