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《Sichuan Journal of Physiological Sciences》 2017-03
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Enhanced peripheral chemoreceptive reflex activity and the involved mechanism in conscious rats with chronic heart failure

Tang Yu-hong;Zhou Hua;Zhou Li-ming;Ding Yan-feng;HD Schultz;Department of Physiology,West China School of Basic Medical Sciences and Forensic Medicine,Sichuan University;Department of Pharmacology,West China School of Basic Medical Sciences and Forensic Medicine,Sichuan University;Department of Cellular and Integrative Physiology,University of Nebraska Medical Center;  
Objective:To investigate the mechanisms of the peripheral chemoreceptive reflex in chronic heart failure caused by ischemic cardiomyopathy.Methods:CHF was produced by ligating the left anterior descending coronary artery in SD male rats.VE were measured in conscious rats as an indicator of peripheral chemoreceptive reflex.The Ang Ⅱ levels of CB tissues were measured by radioimmunoassay,and the expression of AT1R and ACE protein in CB tissues were detected by Western blot.Results:CHF model was successfully produced for the morphological and hemodynamic indexes of rats reached the standard of CHF animal model 8 weeks after ligation.The VE in conscious CHF rats under normoxia and hypoxia were higher than that in the sham group(P0.05).The level of AngⅡ of CB tissues in CHF group was significantly higher than that in the sham group(P0.05)by radioimmunoassay;Western blot results showed that compared with the sham group,the expressions of AT1R and ACE in CB tissues increased in CHF group(P0.05).Conclusion:An enhancement of the peripheral chemoreceptive reflex occurs in the conscious rats with ligation-induced CHF and it may contribute to the sympathetic over-activation in the CHF state.Elevated Ang Ⅱ in CB may be involved in the enhancement of CB chemoreceptive reflex via AT1R .
【Fund】: NIH基金(资助编号:PO-1HL 62222)
【CateGory Index】: R541.6
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