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《Journal of Sichuan of Traditional Chinese Medicine》 2006-01
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Analysis on c-fos、CRHmRNA in Rat Brain Induced by Anger and Fear Stress

Liu Xiaowei Qu Hongda Zhang Hongmei Xie Yaning Dong Qiuan Xu Wenxue Xu Li Deng Hongzhu Fu Jiangnan Li Xiaoming.∥Department of Traditional Chinese Medicine,Medical University of South-China(Guangzhou Guangdong 510515)  
Objective:Analyse the diversity of c-fos and CRHmRNA expression in brain in rats with anger and fear stress.Methods:Animal models were established according to Megan E and Takashi's methods respectively.The expression of protein product of c-fos was examined by immunochemical technique The situs hybridisation was used to detect the expression of CRHmRNA.Comparasion is carried out between the anger group and fear group,model group and normal group.Results:Anger and fear could significantly increase the expression of c-fos compared with normal group(P0.05,P0.01).In anger group,c-fos protein expresses especially in hypothalamus,while fear group in amygdala.The two groups vary significantly(P0.01).CRHmRNA expresses especially in hypothalamus,anger and fear could significantly increase the expression compared with the normal group(P0.05,P0.01).The two groups vary significantly(P0.01).Conclusions:Different qualities of anger and fear stress have different expressions of c-fos and CRHmRNA in brain.
【Fund】: 国家自然科学基金资助项目(No.30271567);; 广东省中医药管理局基金资助项目(No.02102074)
【CateGory Index】: R363
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