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《Journal of Sichuan of Traditional Chinese Medicine》 2006-01
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Effect of Carthamustinctorius Linne on Rabbit Mesentery vasomotion Induced by Noradrenaline In Vivo

Di Keping Hao Fengqin Chang Ligong.∥PLA Bethune Military Medical College(Shijiazhuang Hebei 050081)  
Objective:Observing CTL effect on mesentery vasomotion and exploring the No action in the effect.to assure the CTL mechamism in activiting blood to resolve blood stasis.Methods:20 Albino rabbits weighting 2.0~2.5kg were anesthetized with urethane(0.75g/kg) and alpha-chloralose(30mg/kg) intravenously.The rabbits were ventilated with room air via tracheotomy tube.The arterial pressure and breath were monitored with a pressure transducer attached to a polyethylene canuula in the right common carotid artery by four channel polygraph,the intestinal loop was mounted on the stage of an inverted microscope and bathed in balanced Kreb-Ringer solution maintained at 37.5℃.The inside diameter of arterioles were measured manually on a TV monitor using a TV camera mounted on the microscope.Changes of BP and microcirculation were observed after injection of NA intravenously.CTL(200mg/ml/kg) and L-NMMA(10mg/ml) were administered via a cannula in the left carotid artery after topical application of NA(0.8μg) conducted in the measured field.Results:Spontaneous vasomotion can be induced in the measured field after NA topically used.CTL can inhibit vasomotion in vasoconstriction stage,L-NMMA does not influence the effect of CTL on vasomotion.Conclusions:CTL's inhibition on vasomotion does not gain through endogenous NO.
【Fund】: 国家自然科学基金资助项目(No.39070392)
【CateGory Index】: R285.5
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