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Experimental Research on the function of anti-Cancer in the abstracts of pteris Semipinnata L

Dai Bin Cui Liao Wu Tie Deng Yifeng Wu Kefeng.Department of pharmacology,Guangdong key Laboratory for Research and Development of Natural Drugs,Guangdong Medical College(Zhanjiang Guangdong 524023)  
Objective:To observe the cytotoxic effects in vivo of 5F extracted from Pteris semipinnata L.and its toxicity.Methods:MTT assay was used to assess the proliferation of SPCA-1 and K562 cells in vitro treated with 5F,and the inhibitory effects of 5F on S180 tumors were observed in mice with subcutaneous inoculation of the tumor cells,and the inhibitory effects of 5F on Ehrlich Ascites carcinoma were observed in mice with peritoneal inoculation of the tumor cells;At the same time,the thymus index,liver index and spleen index were measured.Results:The 5F significantly inhibited the proliferation of SPCA-1 cells and K562 cells in a dose-dependent in vitro.In the tumor-bearing mice,5F inhibited the development of S180 tumor and prolonged the survival of Ehrlich Ascites carcinoma-bearing mice.Conclusions:5F possesses antitumor effects both in vitro and in vivo.
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