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The influence of Modified XianXiongtaoCheng decoction plus Sheng Mai injection on the Lung tissue of ARDS

Geng Yun~1 Xia Hongmei~2 Ma Chaoying~1.1.School of Pharmacy Southwest Jiaotong University(Eme Sichuan 614204) 2.Jiangxi Xinyu College(Xinyu Jiangxi 336500)  
Objective:Observating the therapeutic function of rats after modified to xianxiongtaocheng decoction and shenmai injection to the ARDS after CLP and discussing the mechanism.Methods:choose SD rats as the experimental subjects.Make the rats(ARDS) models with the CLP.Then pretreating animals respectively by the physiological saline,xianxiongtaocheng decoction and shenmai injection,xianxiongtaocheng decoction,shenmai injection.and contrasting among groups.After made model at 3?6?12?24 the contents of blood gas analysis of rats were dectected.and at 3?12 hours,the apoptosis of lun tissue and nuclear factor-κB expression were measured respectively.Results:After experiments,the PaO_2 and PaCO_2 in the normal group had less obviously differences.with the time delaying,the PaO_2 of model group grandly declining,PaCO_2 grandly rising.and the PaO_2 of all the groups were dropping.but the shenmai injection group and xianxiongtaocheng decoction and shenmai injection group fell less.and had significant difference compared with xianxiongtaocheng decoction group and model group(P0.05);the PaO_2 of model group increasing obviously and had significant difference compared with other four groups(P0.05).but the level of PaCO_2 in the shenmai injection group?xianxiongtaocheng decoction group and xianxiongtaocheng decoction and shenmai injection group changed little significant difference compared with the normal group(P0.05).the NF-κB expression was increasing obviously in the model group.But the NF-κB expression of other groups had obvious fallen(P0.05~0.01),the most was the xianxiongtaocheng decoction and shenmai injection group.Conclusions:The xianxiong taocheng decoction and shenmai injection can highten the level of PaO_2,declined the level of PaCO_2 and abated the impairment level of pulmonary organizations.
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