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Experiment research on effect and the machanism of tectology of bone of female SD rat after taking kidney-reinforcing Chinese herb ZiShen Wan

Zheng Yunxia Yang Renxu Cheng Hong.Chengdu University of Traditional Chinese Medicine(Chengdu Sichuan 610075)  
Objective:To investigate the effect and the mechanism of tectology of bone after kidney-reinforcing Chinese herb Zishenwan applied to gelding osteoporosis female rat.Methods:Female SD rat(n=66,15 weeks old) were randomly assigned to 6 groups of 11 each,the control group were shamly operated;the other groups were performed ovariectomy on both sides.Medicines were given for 12 weeks,beginning from 2 weeks after surgery,then they are killed.Take the outlying 1/3 quarters of thighbone and close 1/3 quarters of shinbone,investigate the tectology of bone;collect the blood,determin E_2 and ALP.Results:lumber number of bone significantly reduce,the bone organization degraded,the number of trabecular reduced,the thickness become thin,the area percent declined.The level of ALP increased and the level E_2 of decreased significantly in model group.Zishenwan group including big,middle,small dosage group,can antagonize these changes which has the statistics meaning,(P0.05).Conclusions:Kidney-reinforcing Chinese herb Zishenwan can improve the tectology of Bone of gelding osteoporosis female rat,the mechanism has relationship with its raising the level of E_2 in blood and reduce of level of ALP to depress the hyper bone turnover.
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