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Research on the intervention of Liu wei DiHuang pill(LDP)on therapeutic effectiveness and adverse reaction of hormonotherapy and immunosuppressive agent in treating systemic Lupus erythematous(SLE)

Lian Ying Zhen Ping Guan Xiaohong Hu Qian Lei Lihua Tao Li.Chengdu Provincial Hospital of Integrative Chinese and Western Medicine(Chengdu Sichuan 610016)  
Objective:To observe the intervention of Liuwei Dihuang pill(LDP) on therapeutic effectiveness and adverse reaction of hormonotherapy and immunosuppressive agent in treating systemic lupus erythematosus.Methods:Patients divided in two groups were medicated with initial dose of prednisone 1mg/kg once a day at 8 am in the morning.After 8 weeks,Medication the dose of prednisone was decreased by 5.0mg every 2 weeks till 30mg/kg per day.Then the prednisone was decreased gradually.The patient of lupus nephnitis were injected cyclophosphamide(CTX) 0.8g once a month.At the same time,the treated group was administrated LDP 8 capsules 3 times per day.Results:Therapeutic effect in the treated group was significant better than that in the control group 96.67%,80.33%(P0.05).Mouth ulcer,liver insufficiency,disorder of mensis and complement C3,24-hour proteinura were improved(P0.05,P0.01).However,as compared with the control group,the improvement was better,and the recurrent rate was lower(P0.05) in the treated group.Scores of Yin-deficiency caused excessive fire syndrome and incidence rate of adverse reaction in the treated group were lower than those in the control group(P0.05,P0.01).Conclusions:LDP can markedly improve the therapentic effectiveness and counteract the adverse reaction of hormonotherapy and immunosuppressive agent in treating systemic lupus erythematosus,and reduce the recurrence of the disease.
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