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Study on the association between traditional Chinese medicine syndrome of Coronary heart disease and polymorphism of C825T of GNB3 gene

Wu Yifen~1 Zhou Yingchun~1 Wang Gang~2 Zhang Xuesen~1 Zhuang Dan~1.TCM Department,()~1Radiation Department,Nan Fang Hospital,Nan Fang Medical University(Guangzhou Guangdong 510515)  
Objective:To explore the relationship between the traditional Chinese medicine syndrome including phlegm damp type(PDS),blood stasis type(BSS)and the syndrome type caused by neither phegm damp nor blood stasis of coronary heart disease(CHD) and polymorphism of C825T of G-protein β3 submit(GNB3) gene.Methods:The GNB3 gene type in 23 patients of CHD of PDS type,22 patients of CHD of BSS type,22 patients of CHD of non-PDS and non-BSS type,20 patients of healthy subjects(control) was determined by PCR assay,also levels of blood pressure,blood fat and BMI was determined.Results:Occurance of 825TT gene type of GNB3 was associated with patients of PDS and BSS.The TT gene type of GNB3 was significantly higher in patients of PDS and BSS than that in other syndrome and control(P0.05).Not only the TT gene type in PDS was higher than that in BSS,but also the difference was not significant(P0.05).Conclusions:825TT gene type of GNB3 may be a risk element of CHD in patients of PDS and BSS.
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