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《Journal of Sichuan of Traditional Chinese Medicine》 2006-07
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The role of Calponin in cholesterol gallstone formation and effects of recipe for dispersing stagnated liver qi to promote Bile flow

Fang Bangjiang Zhu Peiting Zhang Jingzhe Zhang Yiying Pei Xinjun Li Jiong Liang Xiaoqiang Longhua Hospital,Shanghai University of Traditional Chinese Medicine(Shanghai 200032,China)  
Objective:To explore the mechanisms of the prophylacticotherapeutic function of recipe for dispersing stagnated liver qi to promote Bile flow(DSPB)on gallstone.Methods:The guinea pigs were randomly divided into 4 groups,which were normal control group,untreate group,DSPB recipe-treated group and ursodeoxycholic acid(UDCA)-treated group.The guinea pigs of the latter 3 groups were induced gallstones by high-cholesterol diet.UDCA and DSPB recipe were given to the guinea pigs in the corresponding group respectively for seven weeks.The gallstone formation and the expression of Calponin in gallblader were observed.Results:The DSBP recipe was able to prevent the formation of gallstone significantly(P0.01,vs untreated group),which was more effective than UDCA be(P0.01).The expression of Calponin in untreated group was significantly increased as compared with that in normal control(P0.01).Although the expression of Calponin in DSPB recipe-treated group or UDCA-treated group was increased as compared with that innormal control grop(P001,P0.05),they were decreased as compared with that in untreated group(P0.01).There were no significant difference on the expression of Calponin between DSPB recipe-treat group and UDCA-treated group(P0.05).Conclusions:DSPB recipe may decrease the gallstone formation significantly.Its mechanism may be related to down-regulating the expression of Calponin in the smooth muscle of gallbladder and enhance the contractibility of smooth muscle in gallbladder.
【Fund】: 上海市重点学科建设项目(T0304);; 国家中医药管理局中医药科学技术研究专项中医(基础)研究课题(编号:0405JP24)
【CateGory Index】: R285.5
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