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《Journal of Sichuan of Traditional Chinese Medicine》 2006-10
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The effect of rhubarb,oriental wormwood etc.on ultrastructure in cholecystic tissues of diabetic rabbits

Wang Ping~1 Cao Zewei~1 Wei Xiaodong~1 Liu Junhong~1 Bai Jingwen~21.Tianjin Nankai Hospital(Tianjin 300100) 2.Dept.of Ultrastructural Pathology,Tianjin Medical University(Tianjin 300070)  
Objective:To investigate the effect of traditional Chinese herbal medicine on ultrastructure in cholecystic tissues of diabetic rabbits.Methods:Sixty male white rabbits were randomly divided into five groups:diabetic group,group 1 treated by Chinese herbs,group 2 treated by Chinese herbs,group 3 treated by Chinese herbs,normal control group.Diabetic model of rabbits was induced by intravenous injection of alloxan(140mgkg).After establishment of diabetic model,the rabbits blood sugar was controlled near 20mmolL by means of injection of insulin.For the three groups treated by Chinese herbs,a decoction made by a compound prescription was poured into stomach for 6 weeks(one timeday).Then all of the rabbits were killed and the changes of ultrastructure in cholecystic tissues were observed.Results:For the diabetic group,the diabetic angiopathy in cholecysts was observed.For the 3 groups treated by herbs,the lessened diabetic angiopathy in cholecysts,which depended on the different herb prescription,was appeared.Conclusions:Diabetes had resulted in the changes of ultrasturcture in both cholecystic microvascular endotheliocyte and smooth muscle cell.The traditional Chinese medicine,such as rhubarb,oriental wormwood etc.,can effects the changes of ultrastructure in cholecystic tissues resulted from diabetes.
【Fund】: 天津市卫生局科研基金项目(编号:02012)
【CateGory Index】: R285.5
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