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《Journal of Sichuan of Traditional Chinese Medicine》 2011-01
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The Impact of Biejiajian Pill on Transforming Growth Factor β_1(TGF-β_1)of Pumlonary Fibrosis in Rats

Tang Zhiyu1 Li Tianlang1 Chen Yan2 Yang Shuguang1 1.The People′s Hospital of Dechang County(Dechang Sichuan 615500,China) 2.Southwest University of Science and Technology(Mianyang Sichuan 621010,China)  
Objective:To study the mechanism of Biejiajian pill to treat pulmonary fibrosis induced by bleomycin in rats.Methods:The healthy SD rats(50) were randomly divided into normal group,model group,prednisone group,Biejiajian pill group(moderate dose and large dose).Bleomycin was injected in bronchia to make the model of pulmonary fibrosis in rats.After 28 days.The rats were killed and collected specimens to measure the expression of TGF-β1.Results:The expression of TGF-β1 is weak in Biejiajian pill groups of high and moderate dose.Conclusion:Biejiajian pill has a certain treatment effect on the pulmonary fibrosis induced by bleomycin in rats,possibly fulfill through controlling TGF-β1 expression.
【Fund】: 四川省凉山彝族自治州立项课题(项目编号:200909)
【CateGory Index】: R285.5
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