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《Journal of Sichuan of Traditional Chinese Medicine》 2011-01
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Experiment of Anti-inflammatory and Immune Influence and Mechanism on Compatibility of Nux vomica and Dried rehmannia

Liang Xiaodong Tang Yingxue Fan Kaifang Fundamental Medical Acadency,Shangdong University of Traditional Chinese Medicine(Jinan Shandong 250355,China)  
Objective:Adopting the Adjuvants Arthritis(AA) rats to explore the treatment function,exploring mechanism and best compatibility proportion on the compatibility of Nux vomica and Dried rehmannia.Methods:Copying AA model and giving different compatibility proportion water decoction to the Wistar rats.Calculating the rats volume on first,eighth,twelfth,sixteenth,twentieth,twenty-fourth,twenty-eighth day and the coefficient of immune organs.Using the methods of nitrate reductase for NO determination,hydroxylamine for SOD determination,thiobarbituric acid(TBA) for MDA determination.Results:The compatibility had significant inhibitory effect on the joint swelling degree,could protect the immune system response in rats.At the same time,decreasing the contents of NO,MDA in blood serum and increasing the content of SOD,the results were superior to single decoction group.Conclusions:On one hand,the experimentation showes that the compatibility have the better anti-inflammatory and immune system balance effect,the mechanism is that it can lower lipid peroxidation and the restoration of antioxidant enzyme activity.On the other hand,it proves that the best proportion of the compatibility of Nux Vomica and Dried Rehmannia is 1∶6.
【Fund】: 高等学校博士学科点专项科研基金(200804410002)
【CateGory Index】: R285.5
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