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Antioxidant Activity of Extract from Cichorium endivia L.

CHEN Chao-jie1,QIN Hai-lin2,DENG An-jun2,WANG Ai-ping1(1.New Drug Safety Evaluation Center,2.Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050,China)  
Objective To study the antioxidant activity of extract from Cichorium endivia L..Methods C.endivia L.was refluxed with 95% ethanol and defatted with petroleum ether,and then was extracted by ethyl acetate and purified by macroporous resin successively,with ethanol as eluent.After elution with 60% ethanol,the eluate was evaporated,and the residue of the extract was obtained.The antioxidant activity of the extract was measured by 2,2-diphenyl-1-picrylhydrazyl radical(DPPH?) and superoxide anion(O2-·) scavenging capacity assays,and by the test based on haemolysis model induced by 2,2’-azobis(2-amidinopropane) dihydrochloride(AAPH).Results The extract showed the capacity of scavenging radicals of DPP· and O2-·,which was dependent on the concentration of it,and its power to scavenge O2-· was stronger than that of the reference vitamin C.Meanwhile,the extract inhibited haemolysis of rabbit erythrocytes induced by AAPH effectively,indicating that the extract was able to protect the cells and tissues of organism from injury induced by oxidative stress.Conclusion The excellent antioxidant capacity of etract from Cichorium endivia L.provides reference for its application in food and drug.
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