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EFFECTS OF ALCOHOL ON EPICARDIAL HIGH FREQUENCY ELECTROCARDIOGRAM(EHFECG)POWER SPECTRUM IN ISOLATED PERFUSED RABBIT HEART

Yin Lianghong (Department of Physiology,PLA Jinan Junior College of Medicine,Jinan 250022)  
We studied the changes of epicardial high frequency electrocardiogram (EHFECG) power spectrum before and after different concentrations of alcohol perfusion in isolated rabbit heart. Male adult rabbits(n=35)weighing 1.96±0.24Kg were utilized. Hearts were divided into four groups. ①Controls(n=9):hearts were perfused with NTS. ②Alcohol group I(Alc I,n=8),groupⅡ(AlcⅡ,n=8),groupⅢ(AlcⅢ,n=10):isolated hearts were equilibrated with NTS for 60 min, then perfused with NTS containing 45mM,90mMand 135mM alcohol respectively for 120min. EHFECG was recorded with model NHE-1000 microprocessor ECG system. The results as follows: Compared with controls, high concentration of alcohol(90mM and 135mM) had significantly decreased the relative and absolute power contents of the high frequency ranges of 80-300Hz,100-1000Hz.It showed that alcohol had produced the impairment of myocardial cells similar cardial ischemia.
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