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《Journal of Biomedical Engineering Research》 2007-01
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Experimental Investigations of the Injectable rhBMP-2 osteoinductive Material in Repairing the Segmental Rabbit Radius Defects

CUI Geng1,LI Jie2,LEI Wei3,HU Yun-yu3,Lü Rong3,TANG Pei-fu1,LIANG Yu-tian1,TAO Sheng1,ZHANG Qun1,GUO Yi-zhu1,LIANG Xiang-dang1,WANG Yan1(1.Institute of Orthopedics,General Hospital of PLA,Beijing 100853,China;2.Department of Gynecology and Obstetrics,General Hospital of PLA,Beijing 100853;3.Institute of Orthopedics,Xijing Hospital,4th Military Medical University,Xi'an 710032,China)  
To investigate the effect of the injectable osteoinductive material with Fibrin sealant as a carrier compounded with rhBMP-2 in repairing the segmental rabbit radius defects and provide experimental foundation for the clinical application in the future.Experiment rabbits were divided into experiment group(FS+rhBMP-2) and control group(FS).15mm bone defects were created in the 28 rabbits radii and the composites of experiment group(FS+rhBMP-2) and control group(FS) were percutaneously injected into the defects after primary injuries wound being sutured respectively from the normal skin.The effect of repairing the segmental rabbit radius′s defects was evaluated by radiography,histology,bone mineral density(BMD) in 4,8,16,24 weeks after operation.Results showed the higher repairing capability and rate of osteogenesis in experiment group(FS+rhBMP-2) compared to control group(FS)(P0.01)and the bone defects of the experimental group were repaired utterly in 24 weeks after operation,but the bone defects of the control group couldn't be repaired.It proves that the injectable osteoinductive material with fibrin sealant as a carrier compounded with rhBMP-2 has effective repairing ability to the rabbit radius′s defects.
【CateGory Index】: R318.08;R687.3
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【References】
Chinese Journal Full-text Database 2 Hits
1 Zhan Yu-lin1,Kurexi Yunusi2,Huang Guo-hong2,Bai Jing-ping3 1Department of Orthopaedics,First Affiliated Hospital,Xinjiang Medical University,Urumqi 830054,Xinjiang Uygur Autonomous Region,China;2Department of Molecular Biology,Basic Medical College,Xinjiang Medical University,Urumqi 830011,Xinjiang Uygur Autonomous Region,China;3Cancer Hospital Affiliated to Xinjiang Medical University,Urumqi 830011,Xinjiang Uygur Autonomous Region,China;Rabbit bone marrow mesenchymal stem cells transfected with pIRES2-EGFP-BMP-2 eukaryotic expression plasmid[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2008-47
2 LI Zhihong, HUANG Shujie, GUAN Jing, WU Jimin, ZHANG Xizheng.Institute of Medical Equipment, Academy of Military and Medical Sciences, Tianjin, 300161, P.R.China.;DEVELOPMENT OF INJECTABLE BONE REPAIR BIOMATERIALS[J];Chinese Journal of Reparative and Reconstructive Surgery;2009-11
【Citations】
Chinese Journal Full-text Database 4 Hits
1 ZHENG Zheng-Ting; MA Ping, LU Rong;WANG Jun(Institute of Orthopaedics, Xijing Hospital, FourthMilitary Medical University, Xi'an 710033, China);Reparation of bone defect and nonunion by percutaneous injection of bone morphogenetic protein andred bone marrow in rabbits[J];Journal of The Fourth Military Medical University;1999-08
2 Li Yafei, Hu Yunyu, Lu Rong, et al. Institute of Orthopaedics,Beijing General Army Hospital,Beijing 100700;The Effects of Four Different Soluble Delivery Vehicles on Bone Morphogenetic Protein in Bone Induction in Mice[J];CHINESE JOURNAL OF ORTHOPAEDICS;1997-02
3 Chen Keming, Liu Xingyan, Ge Baofeng, et al. Orthopaedic Institute of Lanzhou General PLA Hospital, Lanzhou 730050;Studies on Fibrin as A Carrier of Bone Morphogenetic Protein[J];CHINESE JOURNAL OF ORTHOPAEDICS;1998-04
4 CUI Geng,HU Yun-yu,LEI Wei,et al.Institute of Orthopedics,Xijing Hospital,the 4th Military Medical University,Xi'an,710032;Influence of the Injectable Osteoinductive Material on the Proliferation and the Expression of Type Ⅰ Collagen and Alkaline Phosphatase of Marrow Stromal Cell of Rabbit[J];The Orthopedic Journal of China;2003-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Jian jun,LI Bing cang(Research Institute of Surgery,Third Military Medical University,Chongqing 400042,China);Study of fracture healing and it's local gene therapy[J];Journal of Traumatic Surgery;2003-03
2 ZHANG Tao,WANG Dao-xi,LI Xiao-fei,et al.Department of Thoracic Surgery,Tangdu Hospital,Fourth Military Medical University,Xi'an,710038,China;A Comparative Study on Cartilage Induction by Bone Morphogenetic Protein Mixed With Different Carriers in Canine Tracheal Autografts[J];Journal of Chinese Physician;2002-11
3 QIN Hui, XU Jian zhong, ZHOU Qiang, WANG Xu quan, LUO Fei, ZHAO Min, ZHU Hao (Department of Orthopaedics, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Effects of two different methods of tissue engineered bone on cell adhesiveness and proliferation in vitro[J];Acta Academiae Medicinae Militaris Tertiae;2004-11
4 QIN Hui, XU Jian-zhong, WANG Xu-qian, HE Qing-yi, LUO Fei, ZHU Hao, YIN Zhi-hua (Department of Orthopedics, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Ectopic bone formation of tissue engineering bone constructed with diphasic seeding technique[J];Acta Academiae Medicinae Militaris Tertiae;2005-16
5 ZHANG Yu1,CHEN Ming2,GAO Jie1 (1Department of Stomatology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,2Department of Stomatology,The Second Hospital Affiliated to General Hospital of PLA,Beijing 100091,China);Nell-1 transferred BMSC combined with absorbable fibrin glue repairs mandible defect in dogs[J];Acta Academiae Medicinae Militaris Tertiae;2008-14
6 ZHENG Zheng-Ting; MA Ping, LU Rong;WANG Jun(Institute of Orthopaedics, Xijing Hospital, FourthMilitary Medical University, Xi'an 710033, China);Reparation of bone defect and nonunion by percutaneous injection of bone morphogenetic protein andred bone marrow in rabbits[J];Journal of The Fourth Military Medical University;1999-08
7 LIU Tong-Fang, LIU Jian, MENG Guo-Lin, YUAN Zhi, L Rong, BI Long, WANG Deng-Hu, LIU Yan-Wu, HU Yun-Yu Chinese PLA Institute of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China;Feasibility study of injectable calcium phosphate cement and fibrin sealant as an injectable carrier of bone morphogenic protein[J];Journal of the Fourth Military Medical University;2006-14
8 HUANG Ai-wen1,JIN Dan1,PENG Dao-bo2,PEI Guo-xian1 1Department of Orthopedics and Traumatology,2Department of Blood Transfusion,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;Observation of an injectable tissue-engineered bone constructed with autologous platelet-rich plasma and bone marrow stromal cells[J];Journal of Southern Medical University;2007-03
9 Yu Shenghua, Chai Daozhang, Lin Ganshong, et al. The Second People′s Hospital of Guangzhou, Guangzhou 510150;The effect of bone morphogenetic protein and fibrin glue on the healing of full-thickness defects of articular cartilage[J];Guangdong Medical Journal;1999-10
10 Rong Limin,Li Fobao,Cai Daozhang. Department of Orthopaedic Surgery,The Third Affiliated Hospital of Sun Yat sen University of Medical Sciences,Guangzhou 510630 China;Establishment of the animal model of cervical spondylotic myelopathy[J];Anatomy Research;2001-04
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 WANG Dong-wu,YANG Liu,Dai Gang(Center of Joint Surgery,Southwest Hospital,Third Military Medical University,Chongqing 400038,China);Study of biocompatibility of injectable C/GP gel[J];Chongqing Medicine;2007-09
2 WEI Jie LI Yubao ZUO Yi (Research Center for Nano-Biomaterials, Sichuan University, Chengdu 610064} Supported by the Key Research Program of the Ministry of Science &: Technology, China 001BA310A-7. Manuscript received November 8, 2002; in revised form February 18, 2003. To whom correspondence should be addressed, Tel:(028)85417273,;Injectable bone repairing material of nano-apatite and polymer[J];Chinese Journal of Materials Research;2003-03
3 ;Advances in osteogenesis and delivering of bone morphogenetic proteins-6[J];Acta Academiae Medicinae Militaris Tertiae;2005-16
4 HUANG Ai-wen,JIN Dan,PEI Guo-xian,ZENG Xian-li,HU Ji-jie,LIN Hai-ning(Department of Orthopaedics and Traumatology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China);Injectable tissue-engineered bone made of autologous platelet-rich plasma,fibrin glue and BMSCs for repairing segmental radial defect in rabbits[J];Acta Academiae Medicinae Militaris Tertiae;2007-14
5 ZHAO Liang, LI Qi, LIN Li-jun, ZHANG Li, LIU Cheng-long, DING Chao Department of Orthopaedics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China;Interface shear stress between the artificial bones and injectable calcium phosphate glue:an experimental study in rabbits[J];Journal of Southern Medical University;2009-01
6 YE Jian-dong1,2,WANG Xiu-peng1,2,BAI Bo3,XU Qian3 (1.Key Laboratory of Specially Functional Materials(Ministry of Education),South China University of Technology,Guangzhou 510641,China;2.School of Materials Science and Engineering,South China University of Technology,Guangzhou 510641,China;3.1st Affiliated Hospital of Guangzhou Medical College,Guangzhou 510120,China);Structure and properties of an injectable and degradable calcium phosphate cement[J];Journal of Functional Materials;2008-02
7 YUAN Quan . Department of Orthopedic ,Union Hospital ,Tongji Medical College ,Huazhong University of Science and Technology,Wuhan 430022,China;Progress in Bone morphogenetic protein gene in bone tissue engineering[J];;2005-06
8 Cheng Wenjun,Jin Dan,Pei Guoxian,et al.Department of Orthopaedics and Traumatology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;Feasibility of chitosan-beta-tricalcium phosphate as an injectable bone tissue engineering scaffold material[J];Medical Journal of Chinese People's Liberation Army;2007-02
9 CHEN Dong,ZHANG Peng,LIU Guo-hui;Advances on bone graft biomaterial substitutes[J];Journal of Clinical Orthopaedics;2007-04
10 FEI Zheng-qi1,HU Yun-yu1,WU Dao-cheng2,WU Hong2,PU Qin3(1.Institute of Orthopeadics,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,Shanxi,China;2.Department of Chemistry,Fourth Military Medical University,Xi'an 710032,Shanxi,China;3.Department of Biochemistry,Fourth Military Medical University,Xi'an 710032,Shanxi,China);Preparation and osteogenic activity of rhBMP-2 loaded/poly(lactic-co-glycolic acid) microsphere[J];Biomedical Engineering and Clinical Medicine;2006-03
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 /Bai Menghai; GeBaofeng; Yang Chao; et al. (The Institute of Or-thopaedic and Traumatology,General Hospital ofLanzhou Command,PLA,Lanzhou 730050);Clinical Application of Composite BovineBone Morphogenetic Protein[J];CHINESE JOURNAL OF ORTHOPAEDICS;1995-01
2 Li Yafei, Hu Yunyu, Lu Rong, et al. Institute of Orthopaedics,Beijing General Army Hospital,Beijing 100700;The Effects of Four Different Soluble Delivery Vehicles on Bone Morphogenetic Protein in Bone Induction in Mice[J];CHINESE JOURNAL OF ORTHOPAEDICS;1997-02
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