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The Effect of 4% Chitosan to the Contaminated Wound of Rats

TAN Wei1,2,TANG Qizhu1,HE Jinfeng(1.The First Clinical School of Wuhan Uniwersity,Wuhan 430072,China;2.Emergency Department of Hubei Jingzhou Central Hospital,Jinzhou,434020 China;3.Jingzhou Central Hospital,Jinzhou 434020)  
To investigate the effect of 4% Chitosan to the Contaminated wound of rats.The Wistar were used to make the model of Contaminated wound,and sprayed the wounds use 4% Chitosan(experimental group)、BFGF(positive control group)and Saline(negative control group)Separately.The results: (1)The healing rate of 4% Chitosan group higher than the Saline group and BFGF group at the 3,7,14,21 day.(2)the healing time of 4% Chitosan was(17.11±1.25) d, the healing time of BFGF is(19.21±1.12) d,but the Saline group is no healing.(3)Bacterial quantification under the scab finded that the Saline group was(4.22±1.65) log cfu/g,the BFGF group was(3.29±0.98) log cfu/g and the 4% Chitosan group was(2.52±1.01) log cfu/g.4% Chitosan can inhibit the Bacterial growing of the wound,improve cure rate of the wound and decrease the healing time.
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