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Study on Pharmacokinetics Model for Targeted Drug Delivery Systems

GE Jianjun1,2,LI Lingbing1(1.Department of Pharmaceutics,Shandong University,Jinan 250012,China;2.Zaozhuang Science and Technology College,Zaozhuang 277000,China)  
To establish the mathematical model for targeted drug delivery systems.The mathematical models for targeted drug delivery systems were developed based on compartment theory and mass conservation theory.The function formulas of drug concentration-time in target organ was established.Based on the target organ drug concentration-time curve,the pharmacokinetics parameters of the target organ could be calculated by the statistical moment.We further detected the practicability of the models by using the experimental data of drug concentration-time curve in target organ of microspheres.The drug concentration-time curve in target organ predicted by mathematical model was agreed with that observed.The established model is useful to describe the pharmacokinetics process in vivo.
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