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Mechanism of Sequential Plasma Exchange and Continuous Blood Purification in the Treatment of Children Hemolytic Uremic Syndrome

RONG Peng,MENG Jianzhong,BAI Xiaoling,WANG Suxia,LIU Wenyuan,YU Ying,GAO Fei(Jinan Military Area General Hospital of PLA,Jinan 250011,China)  
To discuss the mechanism of sequential plasma exchange(PE) and continuous blood purification(CBP) in the treatment of children hemolytic uremic syndrome(HUS) as well as the therapeutic effectiveness.The change in vital sign,some cytokine and biochemical indicator before and after PE+CBP treatment in 21 cases of HUS with conventional treatment were analyzed.After PE+CBP,rapid improvement occurred in systematic conditions,hemolytic control,urine increase.Functions of kidney and other organs gradually recovered to normal,they were all survived patients at acute phase and hemolytic control,the function of kidney and other organ recovered.There were significantly differences in some cytokine and biochemical indicator before and after PE and CBP treatment.PE+CBP treat hemolytic uremic syndrome can significantly remove some of the pathogenic cytokines,stablize internal environment,improve endothelial cell function to enhance efficacy,early treatment can shorten the course of the disease and improve prognosis.
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